Plasticity of the enteric nervous system in patients with intestinal neuronal dysplasia associated with Hirschsprung's disease: a report of three patients

Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intestinal neuronal dysplasia could be a primary disorder or secondary to other diseases of the bowel. The aim of this study was to assess the plasticity of the enteric nervous system in patients with Hirschsprung's disease-associated intestinal neuronal dysplasia and its ability to evolve spontaneously to normal innervation patterns. Since we prospectively introduced the assessment of the enteric nervous system of the ganglionated bowel in patients operated on for Hirschsprung's disease, 31 patients have been operated on for Hirschsprung's disease in our institution between 1995 and 2002. Among these patients, nine suffered postoperatively from severe constipation and five from bouts of entocolitis. IND was found in eight of them. We studied the evolution of the innervation in three of these patients by repeated serial full-thickness biopsies of the colon. All three patients underwent a colostomy before or after the pull-through procedure. Histopathological assessment of the enteric nervous system was made with conventional acetylcholinesterase histochemistry, rapid acetylcholinesterase histochemistry and immunohistochemistry for the Protein Gene Product 9.5 and the antigen CD56. This evolution was compared with the clinical outcome of bowel function. In our three patients with Hirschsprung's disease-associated intestinal neuronal dysplasia, this form of dysganglionosis evolved to normal innervation patterns within a period ranging from 9 to 18months. This evolution was accompanied by an improvement of bowel function in all. We conclude that Hirschsprung's disease-associated intestinal neuronal dysplasia can evolve to a normal innervation, at least under certain circumstances such as a colostomy. Specific histopathological techniques are required to assess accurately the enteric nervous syste

Interstitial cells of Cajal are normally distributed in both ganglionated and aganglionic bowel in Hirschsprung's disease

Surgery for Hirschsprung's disease is often complicated by post-operative bowel motility disorders. The impact of intestinal neural histology on the surgical outcome has been previously studied, but no information is available concerning the influence of the distribution of interstitial cells of Cajal (ICC) on these complications. These cells are considered to be pacemakers in the gastrointestinal tract. The aim of this study was to assess the distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease and confront these results with the clinical outcome. Using immunohistochemistry for light microscopy, we compared the pattern of distribution of ICC in the proximal segment of resected bowel in Hirschsprung's disease with that in normal colon. We correlated these results with the corresponding neural intestinal histology determined by CD56 and the protein gene product 9.5 immunohistochemistry. The distribution of ICC in the proximal segment of resected bowel is identical to that of normal colon, regardless of normal or abnormal colon innervation. ICC distribution does not seem to contribute to post-operative bowel motility disorders in patients operated for Hirschsprung's diseas

PREFACE

Abstract. Simply defined, a Smart City is a city overlaid by a digital layer, which is used for the governance of the city. A Smart City uses intelligent technology to enhance our quality of life in urban environments, bringing together people and data from disparate sources such as sensors, demographics, topographic and 3D mapping, Building Information Models and many more. Increasingly, Smart Cities use this data in a variety of ways, to address key challenges related to transportation, communications, air quality, noise, well-being of the citizens, decision making relating to education and health and urban planning, as well as in relation to initiatives such as startups and fostering economic growth and employment within the city. As more data becomes available, the challenges of storing, managing and integrating such data are also multiplied.The first Urban Data Management Symposium (UDMS) was held in 1971 in Bonn, Germany, made the choice of hosting the 6th international conference on Smart Data and Smart Cities (SDSC) in Stuttgart a very natural one. SDSC was established in 2016 as the successor of the UDMS, and this year we celebrate the 40th anniversary of the series of symposia and conferences. The SDSC 2021 will be part of the scientific week on intelligent cities at HFT Stuttgart. Together four events were held during the week of 14th – 17th September 2021, and alongside SDSC participants were invited to attend the "Energy, water and food for the cities of the future" conference, the "LIS-City – liveable, intelligent, and sustainable City" workshop, and the mobility day Stuttgart. Participant interaction – and the ability to attend sessions across the four events – was particularly encouraged. SDSC 2021 itself was organised by the Urban Data Management Society (UDMS www.udms.net), ISPRS and HFT Stuttgart (the University of Applied Science Stuttgart), and Professor Volker Coors Chaired the SDSC committee.As in previous years, three key conference themes were proposed to represent the Smart Cities: Smart Data (sensor network databases, on-the-fly data mining, geographic and urban knowledge modeling and engineering, green computing, urban data analytics and big data, big databases and data management), Smart People (volunteered information, systems for public participation) and Smart Cities (systems of territorial intelligence, systems for city intelligence management, 3D modeling of cities, internet of things, social networks, monitoring systems, mobility and transportation, smart-city-wide telecommunications infrastructure, urban knowledge engineering, urban dashboard design and implementation, new style of urban decision-making systems, geovisualization devoted to urban problems, disaster management systems).This volume consists of 18 papers, which were selected from 41 submissions on the basis of peer review. These papers present novel research concerning the use of spatial information and communication technologies in Smart Cities, addressing different aspects relating to Smart Data. Selected papers tackle different aspects of Smart Cities: transport, sustainable mobility; dashboards and web GIS; citizen engagement and participation; sensors; urban decision making.The editors are grateful to the members of the Scientific Committee for their time and valuable comments, which contributed to the high quality of the papers. Reviews were contributed by: Alias Abdul-Rahman, Giorgio Agugiaro, Ken Arroyo Ohori, John Barton, Martina Baucic, Filip Biljecki, Lars Bodum, Pawel Boguslawski, Azedine Boulmakoul, Matteo Caglioni, Caesar Cardenas, Eliseo Clementini, Volker Coors, Youness Dehbi, Abdoulaye Abou Diakité, Adil El Bouziri, Claire Ellul, Tarun Ghawana, Gesquiere Gilles, Didier Grimaldi, Ori Gudes, Stephen Hirtle, Martin Kada, Lamia Karim, Robert Laurini, Christina Mickrenska-Cherneva, Christopher Petit, Alenka Poplin, Ivana Racetin, Dimos Pantazis, Preston Rodrigues, Camilo Leon Sanchez, Genoveva Vargas Solar, Nils Walravens, Parag Wate, Besri Zineb, Sisi Zlatanova. We are also grateful to the work of the local organising committee at HFT Stuttgart, without whom this conference would not have been possible

PREFACE

Abstract. Simply defined, a Smart City is a city overlaid by a digital layer, which is used for the governance of the city. A Smart City uses intelligent technology to enhance our quality of life in urban environments, bringing together people and data from disparate sources such as sensors, demographics, topographic and 3D mapping, Building Information Models and many more. Increasingly, Smart Cities use this data in a variety of ways, to address key challenges related to transportation, communications, air quality, noise, well-being of the citizens, decision making relating to education and health and urban planning, as well as in relation to initiatives such as startups and fostering economic growth and employment within the city. As more data becomes available, the challenges of storing, managing and integrating such data are also multiplied.The first Urban Data Management Symposium (UDMS) was held in 1971 in Bonn, Germany, made the choice of hosting the 6th international conference on Smart Data and Smart Cities (SDSC) in Stuttgart a very natural one. SDSC was established in 2016 as the successor of the UDMS, and this year we celebrate the 40th anniversary of the series of symposia and conferences. The SDSC 2021 will be part of the scientific week on intelligent cities at HFT Stuttgart. Together four events were held during the week of 14th – 17th September 2021, and alongside SDSC participants were invited to attend the "Energy, water and food for the cities of the future" conference, the "LIS-City – liveable, intelligent, and sustainable City" workshop, and the mobility day Stuttgart. Participant interaction – and the ability to attend sessions across the four events – was particularly encouraged. SDSC 2021 itself was organised by the Urban Data Management Society (UDMS www.udms.net), ISPRS and HFT Stuttgart (the University of Applied Science Stuttgart), and Professor Volker Coors Chaired the SDSC committee.As in previous years, three key conference themes were proposed to represent the Smart Cities: Smart Data (sensor network databases, on-the-fly data mining, geographic and urban knowledge modeling and engineering, green computing, urban data analytics and big data, big databases and data management), Smart People (volunteered information, systems for public participation) and Smart Cities (systems of territorial intelligence, systems for city intelligence management, 3D modeling of cities, internet of things, social networks, monitoring systems, mobility and transportation, smart-city-wide telecommunications infrastructure, urban knowledge engineering, urban dashboard design and implementation, new style of urban decision-making systems, geovisualization devoted to urban problems, disaster management systems).This volume consists of 14 papers, which were selected from 41 submissions on the basis of double blind review, with each paper being reviewed by a minimum of three reviewers. These papers present novel research concerning the use of spatial information and communication technologies in Smart Cities, addressing different aspects of Smart Data and Smart Citizens. The selected papers tackle different aspects of Smart Cities: 3D; Citizen Engagement; transport, sustainable mobility; dashboards and web GIS; citizen engagement and participation; sensors; urban decision making.The editors are grateful to the members of the Scientific Committee for their time and valuable comments, which contributed to the high quality of the papers. Reviews were contributed by: Alias Abdul-Rahman, Giorgio Agugiaro, Ken Arroyo Ohori, John Barton, Martina Baucic, Filip Biljecki, Lars Bodum, Pawel Boguslawski, Azedine Boulmakoul, Matteo Caglioni, Caesar Cardenas, Eliseo Clementini, Volker Coors, Youness Dehbi, Abdoulaye Abou Diakité, Adil El Bouziri, Claire Ellul, Tarun Ghawana, Gesquiere Gilles, Didier Grimaldi, Ori Gudes, Stephen Hirtle, Martin Kada, Lamia Karim, Robert Laurini, Christina Mickrenska-Cherneva, Christopher Petit, Alenka Poplin, Ivana Racetin, Dimos Pantazis, Preston Rodrigues, Camilo Leon Sanchez, Genoveva Vargas Solar, Nils Walravens, Parag Wate, Besri Zineb, Sisi Zlatanova. We are also grateful to the work of the local organising committee at HFT Stuttgart, without whom this conference would not have been possible

HBIM FOR THE SURVEYING, ANALYSIS AND RESTORATION OF THE SAINT JOHN THE THEOLOGIAN CATHEDRAL IN NICOSIA (CYPRUS)

Abstract. The present study illustrates the results of an interdisciplinary collaboration between the Mediterranean Laboratory of Survey and Diagnostics for Architecture (RDA) of the Department of Civil Engineering and Architecture (DICAR) of the University of Catania in Italy and the Andreas Pittas Laboratories for Art Characterisation (APAC) of the Science and Technology in Archaeology Research Center (STARC) of the Cyprus Institute in Cyprus. The research focused on the application of an H-BIM approach in the study of a Mediterranean iconic heritage asset, the St. John Cathedral of Nicosia, built in 1662 on the remains of a monastery from the 15th century. The adopted methodology has provided the framework for a dynamic investigation, constantly evolving along several dimensions: historical, geometric spatial, architectural-constructive identification and mapping of degrade, interpretation of degenerative causes and design proposals.</p

PREFACE

n/

PREFACE

n/

Plasticity of the enteric nervous system in patients with intestinal neuronal dysplasia associated with Hirschsprung's disease: a report of three patients

Intestinal neuronal dysplasia is a controversial form of dysganglionosis that has been described both as an isolated disorder and in association with Hirschsprung's disease. It has been blamed for the bad outcome of bowel function in patients operated on for Hirschsprung's disease. According to various authors, intestinal neuronal dysplasia could be a primary disorder or secondary to other diseases of the bowel. The aim of this study was to assess the plasticity of the enteric nervous system in patients with Hirschsprung's disease-associated intestinal neuronal dysplasia and its ability to evolve spontaneously to normal innervation patterns. Since we prospectively introduced the assessment of the enteric nervous system of the ganglionated bowel in patients operated on for Hirschsprung's disease, 31 patients have been operated on for Hirschsprung's disease in our institution between 1995 and 2002. Among these patients, nine suffered postoperatively from severe constipation and five from bouts of entocolitis. IND was found in eight of them. We studied the evolution of the innervation in three of these patients by repeated serial full-thickness biopsies of the colon. All three patients underwent a colostomy before or after the pull-through procedure. Histopathological assessment of the enteric nervous system was made with conventional acetylcholinesterase histochemistry, rapid acetylcholinesterase histochemistry and immunohistochemistry for the Protein Gene Product 9.5 and the antigen CD56. This evolution was compared with the clinical outcome of bowel function. In our three patients with Hirschsprung's disease-associated intestinal neuronal dysplasia, this form of dysganglionosis evolved to normal innervation patterns within a period ranging from 9 to 18 months. This evolution was accompanied by an improvement of bowel function in all. We conclude that Hirschsprung's disease-associated intestinal neuronal dysplasia can evolve to a normal innervation, at least under certain circumstances such as a colostomy. Specific histopathological techniques are required to assess accurately the enteric nervous system

Cerebral MRI on fetuses submitted to repeated cocaine administration during the gestation: an ovine model

The aim of this study was to determine the role of Magnetic Resonance Imaging (MRI) in investigating fetal cerebral lesions induced by long term exposure to cocaine during sheep pregnancy. Cerebral Magnetic Resonance Imaging was performed on two groups of fetuses at 125 days of gestation (normal gestation: 145 days). The control group consisted of eight fetuses of four pregnant ewes. The study group consisted of eight fetuses of four pregnant ewes receiving daily 140 mg/kg injection of cocaine from day 60 until delivery. The following MR sequences were applied: T1-weighted FLASH, and T2-weighted Fast-Spin-Echo. Cerebral images were evaluated semi quantitatively using the following criteria: Heterogenicity, contrast between grey and white matter, contours irregularity, hyposignal, lateral ventricle sizes. The brightness distribution and homogenicity of the images were analysed by means of edge pair distributions using a new computerized method originally designed for ultrasound images analysis developed by Ultrasight inc (USA). (1) Flash T1: Heterogenic areas and irregular contours were more frequent in cocaine exposed fetuses. The contrast between grey and white matter was more important in the cocaine group. Hyposignal was found only in the cocaine group. Enlarged lateral ventricle occurred more frequently in the cocaine group. (2) Spin echo T2: The contrast between grey and white matter was higher and the contours of the brain more irregular in the cocaine group. Heterogenicity and hyposignal were also more frequent in this group but the difference with the control group was not significant. The computerized analysis of the contrast density on the cerebral images showed that 88% of the areas exceeding the reference level concerned the cocaine group, while only 14% of the areas exceeding the reference level concerned the control group. Long term exposure to cocaine induces cerebral tissue modifications, in favor of an advanced maturation and the development of hypoxic lesions. The histology of the brains confirmed in the cocaine group, the existence of hypoxic lesions with gliosis, perivascular edema and hemorrhages, and neuronal death

PREFACE

Simply defined, a Smart City is a city overlaid by a digital layer, which is used for the governance of the city. A Smart City uses intelligent technology to enhance our quality of life in urban environments, bringing together people and data from disparate sources such as sensors, demographics, topographic and 3D mapping, Building Information Models and many more. Increasingly, Smart Cities use this data in a variety of ways, to address key challenges related to transportation, communications, air quality, noise, well-being of the citizens, decision making relating to education and health and urban planning, as well as in relation to initiatives such as startups and fostering economic growth and employment within the city. As more data becomes available, the challenges of storing, managing and integrating such data are also multiplied.This increasing interest in Smart Cities world-wide, along with a growing understanding of the importance of integrating “Smart” data with other data and wider applications for the benefit of citizens, made the choice of hosting the third Smart Data, Smart Cities conference in Delft &ndash; in conjunction with three other conferences &ndash; a very natural one. Together the four conferences were held during the week of 1st&ndash;5th October 2018, and alongside SDSC participants were invited to attend the ISPRS Technical Commission IV Symposium, the 13th 3D GeoInfo Conference and the 6th International FIG Workshop on 3D Cadastres. Participant interaction – and the ability to attend sessions across the four events – was particularly encouraged. SDSC 2018 itself was organised by the Urban Data Management Society (UDMS www.udms.net), ISPRS and TU Delft (the Delft University of Technology), and Professor Volker Coors Chaired the SDSC committee.As in previous years, three key conference themes were proposed to represent the Smart Cities: Smart Data (sensor network databases, on-the-fly data mining, geographic and urban knowledge modeling and engineering, green computing, urban data analytics and big data, big databases and data management), Smart People (volunteered information, systems for public participation) and Smart Cities (systems of territorial intelligence, systems for city intelligence management,3D modeling of cities, internet of things, social networks, monitoring systems, mobility and transportation, smart-city-wide telecommunications infrastructure, urban knowledge engineering, urban dashboard design and implementation, new style of urban decision-making systems, geovisualization devoted to urban problems, disaster management systems).This volume consists of 7 papers, which were selected from 34 submissions on the basis of peer review. These papers present novel research concerning the use of spatial information and communication technologies in Smart Cities, addressing different aspects relating to Smart Data. Selected papers tackle different aspects of Smart Cities: transport, sustainable mobility; dashboards and web GIS; citizen engagement and participation; sensors; urban decision making.The editors are grateful to the members of the Scientific Committee for their time and valuable comments, which contributed to the high quality of the papers. Reviews were contributed by: Giorgio Agugiaro, Maria Antoniabrovelli, Ken Arroyoohori, Martina Baucic, Michela Bertolotto, Pawel Boguslawski, Azedine Boulmakoul, Caesar Cardenas, Ofelia Cervantes, Volker Coors, Isabel Cruz, Vincenzo Delfatto, Claire Ellul, Tarun Ghawana, Gesquiere Gilles, Gerhard Groeger, Eberhard Gulch, Jan-Henrik Haunert, Stephen Hirtle, Umit Isikdag, Martin Kada, Snjezana Knezic, Robert Laurini, Liu Liu, Ed Manley, Viviana Mascardi, Marco Minghini, Raul Monroy, Regina Motz, Beniamino Murgante, Marco Painho, Dev Paudyal, Alenka Poplin, Ivana Racetin, Ismail Rakip Karas, Preston Rodrigues, David Sol, Wei Tu, Wei Tu, Genoveva Vargas, Kavita Vemuri, Edward Verbree, Mingshu Wang, Maribel Yasminasantos, Sisi Zlatanova. We are also grateful to the work of the local organising committee at TU Delft, without whom this conference would not have been possible.</p